New Step by Step Map For cees dekker
New Step by Step Map For cees dekker
Blog Article
2009, discovery of a brand new phenotype for micro organism in slender nanofluidic slits; and 1st detection of community protein buildings together DNA applying good-point out nanopores
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination functionality.
Back in 1991, Sumio Iijima from the NEC Corporation had reported the synthesis of carbon nanotubes. Band structure calculations recommended that these nanotubes could exhibit metallic band conduction. This could be a substantial benefit more than the conducting polymers we had explored, which were, actually, disordered semiconductors providing simply variable-assortment hopping conductivity.
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
That is a aspiration of mine and we established to work by using a delicious dose of naivety. That is a thing that will probably produce impressive results in the for a longer time time period, but that does not subject. You shouldn't only want to operate around the inquiries of tomorrow, but will also around the inquiries of your day right after tomorrow.’
Our research ranges from the biophysics of DNA to synthetic cells and beyond. Please take a look down below for the spectrum of our latest initiatives.
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on learning cell division with micro organism on chip, even though his greatest interest is during the route of recognizing artificial cells.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
2003, shown the 1st biosensors manufactured from a carbon nanotube; settled the structure and system of DNA repair service proteins; and discovery of a different strategy for fabricating sound-state nanopores for DNA translocation
Very amazing, but that wasn’t definitely in which my fascination lay. I wanted to pioneer and I experienced the sensation that was not doable, because the most intriguing elementary insights had previously been uncovered. But my industry had produced quite a few exciting new resources to measure particular person molecules. I made a decision which i wanted to use this to biology, to take a look at it from the Actual physical standpoint.’
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement from the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
2005, cees dekker discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-range conformational alterations in Mre11/DNA mend complexes; and first power measurements with a DNA molecule inside a nanopore
Reliable-condition nanopores have established being a shockingly multipurpose probe for one-molecule Assessment of DNA. I'll explain a number of our modern results – exclusively DNA knots – and also our initiatives to grow the capabilities of sound-state nanopores even additional, within the direction of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.